01 - Whisk buttermilk with salt, garlic powder, onion powder, cayenne, and black pepper in a large bowl. Submerge chicken pieces completely. Cover and refrigerate minimum 2 hours, preferably overnight for maximum flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne, and baking powder in a separate bowl. Mix thoroughly to distribute spices evenly throughout the flour mixture.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, ensuring thick, even coating on all surfaces. Arrange on wire rack and rest 10 minutes to set coating.
04 - Pour vegetable oil into deep fryer or heavy pot to depth of 2-3 inches. Heat to 350°F, maintaining steady temperature throughout frying process.
05 - Lower chicken pieces into hot oil in small batches without overcrowding. Fry 12-15 minutes, turning occasionally for even browning, until golden brown and crispy. Verify internal temperature reaches 165°F.
06 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest 5 minutes before serving to retain juices and ensure crisp coating.